Milk thistle is a herbal drug that has been used for thousands of years to treat many different health problems. Taking milk thistle with this hepatitis C medication might increase levels of the drug in your blood plasma. In 2010, a double-blind, placebo-controlled study compared the effects of milk thistle to the antidepressant Prozac (fluoxetine) in treating OCD (600 milligrams of milk thistle vs 30 milligrams of Prozac daily). Talk to your doctor before taking milk thistle if you're taking raloxifene. Silibinin, a flavonoid derived from milk thistle (Silybum marianum), has been used as a hepato-protectant in the clinical treatment of liver diseases. Milk Thistle seeds contain the highest concentrations of the active compound, silymarin. In this study, the effect of silibinin on Aβ-induced anxiety/depression-like behaviors in rats was investigated. As Little Bear said, milk thistle can cause a reaction in those with a rag weed allergy - like me. Milk thistle may affect how your liver processes this osteoporosis medication, causing higher levels of the drug in your bloodstream. Other uses not proven with research have included treating malaria , mushroom poisoning , spleen or gallbladder problems, menstrual problems, liver problems (such as … One study has shown that milk thistle seed extract has estrogenic effects and effects on memory by estrogen. Also known by its scientific name, Silybum marianum, milk thistle grows mostly in California, although it can be grown in many other warm climates as well. Some even claim that milk thistle is effective in treating depression and anxiety, but there’s not enough research to support these claims. Also, as they said, it's use is for protecting and detoxing the liver. Some research also talks about the importance of milk thistle in treating anxiety and depression – but we need more information on this before we come to conclusions. Depression and anxiety are associated with increased risk of developing AD. The authors of this study note that silybin shows promise in memory impairment diseases.3 In fact, in studies where high doses were used for long periods, only about 1% of people experienced side effects ( 1 ). Simeprevir. As a woman prepares to end her childbearing years, hormonal changes take place. So it would be unusual for it alone to be responsible relieving gastro issues, but I sure wouldn't say … Typical, everyday stresses can seem even more overwhelming than before the start of menopause. Milk thistle as a beauty product When applied topically, milk thistle can reduce inflammation and improve skin conditions. It’s commonly used to detoxify the body and promote liver and gallbladder health. Milk thistle is a natural herb with antioxidant and anti-inflammatory properties. Milk thistle may have been combined with other plants or extracts in a specific preparation to treat these conditions. 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